Thorne Basic Prenatal is formulated with methylfolate rather than a synthetic form of folic acid. Research suggests that people who have been diagnosed with the MTHFR gene mutation have a harder time converting folate into its useable form of methylfolate. If you have a history of miscarriages or implantation issues, you might find it useful to find our if you carry this What’s puzzling is that som women who carry this mutation have had one or more full term pregnancies before learning about MTHFR.